Essentials of glycobiology

Proteins That Bind Sulfated Glycosaminoglycans - Essentials of Glycobiology - NCBI Bookshelf

Glycosaminoglycans bind to many different classes of proteins mostly through electrostatic interactions between negatively charged sulfate groups and uronic acids and positively charged amino acids in the protein. This chapter focuses on examples of glycosaminoglycan (GAG)-binding proteins, methods for measuring GAG–protein interaction, and information about three-dimensional structures of the ...

Principles of Glycan Recognition - Essentials of Glycobiology - NCBI Bookshelf

Glycans interact with many types of proteins, as exemplified by their binding to enzymes, antibodies, and glycanbinding proteins (GBPs). Binding of glycans to proteins represents the major way in which the information contained in glycan structures is recognized, deciphered, and put into biological action. This chapter describes the structural and thermodynamic principles of glycan–GBP interact...

Bacterial and Viral Infections -- Essentials of Glycobiology -- NCBI Bookshelf

Infectious diseases remain a major cause of death, disability, and social and economic disorder for millions of people throughout the world. Poverty, poor access to health care, human migration, emerging disease agents, and antibiotic resistance all contribute to the expanding impact of infectious diseases. Prevention and treatment strategies for infectious diseases derive from a thorough under...

Assigned Reading: Chapter 55, Chemical Tools for Inhibiting Glycosylation Essentials in Glycobiology, 3rd edition Chapter 57, Glycans in Biotechnology and the Pharmaceutical Industry Essentials in Glycobiology, 3rd edition Chapter 55, Chemical Tools for Inhibiting Glycosylation Essentials in Glycobiology, 3rd edition

Chemical glycobiology.

Chemical tools have proven indispensable for studies in glycobiology. Synthetic oligosaccharides and glycoconjugates provide materials for correlating structure with function. Synthetic mimics of the complex assemblies found on cell surfaces can modulate cellular interactions and are under development as therapeutic agents. Small molecule inhibitors of carbohydrate biosynthetic and processing e...